冠心病患者持续不明原因的胸痛和呼吸困难-病例报道1例-PersistentUnexplainedChestPainandDyspneainaPatientwithCoronaryArteryDisease-ACaseReport-Abstract摘要Background背景神经源性体位性低血压是指站立时血压持续下降,由自主神经系统功能障碍导致的,其特征是站立时维持血压所需的心率增加不足。在这个病例中,神经源性体位性低血压症状先于帕金森病的诊断。潜在神经源性体位性低血压的诊断显著改变了该患者的治疗过程。Neurogenicorthostatichypotension,asustaineddecreaseinbloodpressureuponstanding,iscausedbyautonomicnervoussystemfailureandcharacterizedbyaninsufficientincreaseinheartrateneededtomaintainbloodpressureuponstanding.Inthiscase,neurogenicorthostatichypotensionsymptomsprecededadiagnosisofParkinsondisease.Adiagnosisofunderlyingneurogenicorthostatichypotensionsignificantlychangedthecourseoftreatmentforthispatient.Casepresentation病例报告一位84岁的妇女被她的初级保健医生转诊给心脏病专家,以评估患者步行几英尺后的劳力性呼吸困难和胸痛。患者的病史包括高血压、甲状腺功能减退和骨关节炎。基于患者持续的症状,患者被考虑冠状动脉狭窄而接受了2次心导管治疗。心导管置入后,患者仍有劳力性呼吸困难和胸痛症状,随后,患者出现吞咽固体食物困难和阵发性头晕。立位评估显示仰卧位血压为/80?mmHg,心率为70次/min。站立3分钟后,患者血压降至/74?mmHg,心率为76次/min。符合体位性低血压的诊断标准,站立时缺乏足够的代偿性心率增加与神经源性原因(即神经源性体位性低血压)一致,倾斜试验结果支持了这一点。虽然非药物的治疗手段最初是成功的,但患者站立时出现头晕、胸痛和呼吸困难的次数更加频繁,患者服用了droxidopa(毫克;每天3次)。Droxidopa显著改善了她的症状,患者诉胸痛缓解,呼吸困难和头晕显著改善。大约6个月后,她被诊断出患有帕金森病。An84-year-oldwomanwasreferredtoacardiologistbyherprimarycarepractitionerforevaluationofexertionaldyspneaandchestpainuponwalkingafewfeet.Hermedicalhistoryincludedhypertension,hypothyroidism,andosteoarthritis.Basedonhercontinuedsymptoms,thepatientunderwent2cardiaccatheterizationsforcoronaryarterystenosis.Afterthecatheterizations,exertionaldyspneaandchestpaincontinued,andsubsequently,dysphagiatosolidfoodsandepisodicdizzinessdeveloped.Orthostaticevaluationshowedasupinebloodpressureof/80?mmHgwithaheartrateof70beatspermin.Uponstandingfor3?min,thepatient’sbloodpressuredecreasedto/74?mmHgwithaheartrateof76beatspermin.Thediagnosticcriteriafororthostatichypotensionweremet,andthelackofanadequate
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